If you've created a valid DNS template, registered and applied the nameservers at your registrar and created a domain in Kloxo the only last step remaining is to execute
If running CentOS:
/etc/init.d/named restart
/etc/init.d/httpd restart
If running Debian
/etc/init.d/bind9 restart
/etc/init.d/apache2 restart
Because Kloxo doesn't do it automatically (hell, Kloxo doesn't even start BIND when installed).